Applied Pharmacokinetics and Pharmacodynamics Principles of Therapeutic Drug Monitoring

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy.

This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Table Of Contents

PART I: BASIC CONCEPTS AND PRINCIPLES 1

1. General Principles of Clinical Pharmacokinetics 3
William E. Evans

2. Guidelines for Collection and Analysis of Pharmacokinetic Data 8
William J. Jusko

3. Critical Evaluation of Methods for Therapeutic Drug Monitoring 30
Victor W. Armstrong and Michael Oellerich

4. Analysis of Pharmacokinetic Data for Individualizing Drug Dosage Regimens 40
John H. Rodman, David Z. D'Argenio, and Carl C. Peck

5. Pharmacodynamics 60
Richard L. Lalonde

6. Influence of Protein Binding and Use of Unbound (Free) Drug Concentrations 82
Janis J. MacKichan

7. Drug Metabolism, Transport, and the Influence of Hepatic Disease 121
Angela D.M. Kashuba, Joohyun J. Park, Adam M. Persky, and Kim L.R. Brouwer

8. Application of Pharmacogenetic Principles to Clinical Pharmacology 165
Mark W. Linder, William E. Evans, and Howard L. McLeod

9. Influence of Renal Function and Dialysis on Drug Disposition 187
Gary R. Matzke and Thomas J. Comstock

10. Special Pharmacokinetic and Pharmacodynamic Considerations in Children 213
Holly D. Maples, Laura P. James, and Cindy D. Stowe

11. Special Pharmacokinetic Considerations in the Obese 231 Robert A. Blouin and Mary H.H. Ensom

12. Dietary Influences on Drug Disposition 242
Mary H.H. Ensom and Robert A. Blouin

PART II: MONITORED DRUGS 257

13. Asthma Management 259
Glenn J. Whelan and Stanley J. Szefler

14. Aminoglycosides 285
Jerome J. Schentag, Alison K. Meagher, and Roger W. Jelliffe

15. Vancomycin 328
Pamela A. Moise-Broder

16. Microbiologic, Clinical, and Economic Outcomes of Dual Individualized Dosing of Antimicrobial Agents 341
Joseph A. Paladino and Jerome J. Schentag

17. Antivirals for HIV 354
Craig R. Rayner, Michael J. Dooley, and Roger L. Nation

18. Digoxin 410
Jerome J. Schentag, Anthony J. Bang, and Jennifer L. Kozinski-Tober

19. Clinical Pharmacokinetics of Oral Antiarrhythmic Drugs 440
Jerry L. Bauman, Harumi Takahashi, and James H. Fischer

20. Phenytoin 463
Michael E. Winter and Thomas N. Tozer

21. Antiepileptic Drugs 491
William R. Garnett, Gail D. Anderson, and Rebeccah J. Collins

22. Cyclosporine 512
Atholl Johnston and David W. Holt

23. Tacrolimus 529
Uwe Christians, Taveesak Pokaiyavanichkul, and Laurence Chan

24. Mycophenolic Acid 563
Arthur Nawrocki, Magdalena Korecka, Sandra Solari, Juseop Kang, and Leslie M. Shaw

25. Sirolimus 595
Barry D. Kahan and Kimberly L. Napoli

26. Anticancer Agents 617
William P. Petros and William E. Evans

27. Heparin—UFH and LMWH 637
Keith A. Rodvold, Sharon M. Erdman, Kelly A. Sprandel, Robert J. Cipolle, and Eleanor S. Pollak

28. Warfarin 715
Stuart T. Haines, Thomas Dowling, and R. Donald Harvey, III

29. Nonsteroidal Anti-Inflammatory Drugs and Coxibs 752
Tilo Grosser

30. Cyclic Antidepressants 781
C. Lindsay DeVane

31. Lithium 798
Tawny L. Bettinger and M. Lynn Crismon

32. Antipsychotics 813
James M. Perel and Michael W. Jann

Appendix: A Critical Assessment of the Outcomes of Therapeutic Drug Monitoring 839
Mary H.H. Ensom and Michael E. Burton
Index 849