Aulton's Pharmaceutics, The Design and Manufacture of Medicines

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms for medicines. An understanding of pharmaceutics is therefore vital to all pharmacists and pharmaceutical scientists who are involved in converting a drug or a potential drug into a medicine that can be delivered safely, efficiently and conveniently to the patient. Professor Aulton's Pharmaceutics has become established as the clearest, most comprehensive textbook on this subject. The book provides pharmacy and pharmaceutical science students with the latest information on all aspects of pharmaceutics.
Key Features

* provides a logical, comprehensive account of drug design and manufacture
* includes the science of formulation and drug delivery
* designed and written for newcomers to the design of dosage forms

New to this Edition

* two new chapters on the principles and practice of sterilization
* dosage-form design and delivery material thoroughly updated
* product stability and stability testing of medicinal products section totally rewritten and expanded to include more of the relevant chemistry
* reflects current and future use of biotechnology products throughout
* changes in our understanding of biopharmaceutics, certain areas of drug delivery and the significance of the solid state all reflected
* new page size and design
* new photographs of equipment and apparatus

Table of Contents

What is ‘pharmaceutics’?
Design of dosage forms
PART ONE: SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN
# Dissolution and solubility
# Properties of solutions
# Rheology
# Surface and interfacial phenomena
# Disperse systems
# Kinetics of product stability
PART TWO: PARTICLE SCIENCE AND POWDER TECHNOLOGY
# Solid-state properties
# Particle size analysis
# Particle size reduction
# Particle size separation
# Mixing
# Powder flow.
PART THREE: PHARMACEUTICAL MICROBIOLOGY AND STERILIZATION
# Fundamentals of microbiology
# Pharmaceutical applications of microbiological techniques
# Action of physical and chemical agents on microorganisms
# Principles of sterilization
# Sterilization in practice
PART FOUR: BIOPHARMACEUTICAL PRINCIPLES OF DRUG DELIVERY
# Introduction to biopharmaceutics
# Gastrointestinal tract – physiology and drug absorption
# Bioavailability – physicochemical and dosage form factors
# Assessment of biopharmaceutical properties
# Dosage regimens
PART FIVE: DOSAGE FORM DESIGN AND MANUFACTURE
# Pharmaceutical preformulation
# Solutions
# Clarification
# Suspensions and emulsions
# Powders and granules
# Granulation
# Drying
# Tablets and compaction
# Modified-release peroral dosage forms
# Coating of tablets and multiparticulates
# Hard gelatin capsules
# Soft gelatin capsules
# Pulmonary drug delivery
# Nasal drug delivery
# Transdermal drug delivery
# Wound dressings
# Rectal and vaginal drug delivery
# Delivery of pharmaceutical proteins
# Packs and packaging
# Microbial contamination, spoilage and preservation of medicines
# Product stability and stability testing
# Pharmaceutical plant design
# Heat transfer and the properties and use of steam