Biochemistry

New Chapters
New chapter-length treatment of Hemoglobin (Chapter 7) adds new insights to a classic example instructors find invaluable in exploring the relationship between structure and function.

New chapter on Drug Development (Chapter 35) draws on fascinating recent case histories to show students how knowledge of biochemical pathways led to the development of recent drugs.


Emphasis on Biological Relevance
Because biochemical pathways make more sense to students when they understand how these pathways relate to the physiology of familiar activities such as digestion,respiration, and exercise, the authors introduce:
• Metabolic regulation discussions emphasizing the everyday conditions that determine regulation: exercise vs. rest; fed vs. fasting
• New pathway integration figures showing how multiple pathways work together under a certain condition, such as running a sprint.
• More physiologically relevant examples throughout the text.


New Tools for Molecular Visualization
A molecular model “primer” explains the characteristics of different types of protein models and examines their strengths and weaknesses.

Figure captions direct students explicitly to the key features of a model.
Greater variety of molecular structures represented throughout.
All illustrated protein structures available online in easy-to-use jmol format

Table of Contents

PART I THE MOLECULAR DESIGN OF LIFE
1. Biochemistry: An Evolving Science
2. Protein Composition and Structure
3. Exploring Proteins and Proteomes
4. DNA, RNA, and the Flow of Genetic Information
5. Exploring Genes and Genomes
6. Exploring Evolution and Bioinformatics
7. Hemoglobin: Portrait of a Protein in Action
8. Enzymes: Basic Concepts and Kinetics
9. Catalytic Strategies
10. Regulatory Strategies
11. Carbohydrates
12. Lipids and Cell Membranes
13. Membrane Channels and Pumps
14. Signal-Transduction Pathways

PART II TRANSDUCING AND STORING ENERGY
15. Metabolism: Basic Concepts and Design
16. Glycolysis and Gluconeogenesis
17. The Citric Acid Cycle
18. Oxidative Phosphorylation
19. The Light Reactions of Photosynthesis
20. The Calvin Cycle and the Pentose Phosphate Pathway
21. Glycogen Metabolism
22. Fatty Acid Metabolism
23 . Protein Turnover and Amino Acid Catabolism

PART III SYNTHESIZING THE MOLECULES OF LIFE
24. The Biosynthesis of Amino Acids
25. Nucleotide Biosynthesis
26. The Biosynthesis of Membrane Lipids and Steroids
27. The Integration of Metabolism
28. DNA Replication, Repair, and Recombination
29. RNA Synthesis and Processing
30. Protein Synthesis
31. The Control of Gene Expression

PART IV RESPONDING TO ENVIRONMENTAL CHANGES
32. Sensory Systems
33. The Immune System
34. Molecular Motors
35. Drug Development