Clinical Trials In Heart Disease, 2nd Edition

Understanding clinical trials and the resulting outcomes is important to understanding the management of cardiovascular health. This new edition (a companion to Braunwald's Heart Disease ) covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice.

This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.

This book offers indispensable guidance for clinical decision-making in all patient care settings!

Features

Evidence-based research to guide clinical practice.
Coverage of treatment trials including Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug therapies for arrhythmias, and pacing.
Expanded section on prevention of cardiac disease
Covers both prevention and treatment.

What's New

* Data and Safety Monitoring Boards in Randomized Trials
* Coronary Artery Bypass Surgery
* Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy
* Postmenopausal Hormone Therapy

Contents

Section I. METHODOLOGY

Chapter 1: Contributions of Basic Research, Observational Studies, and Randomized Trials
Chapter 2: Methodology of Randomized Trials
Chapter 3: Comparative Features of Primordial, Primary and Secondary Prevention Trials
Chapter 4: Principles of Data and Safety Monitoring Boards in Randomized Trials

Section II. TREATMENT TRIALS

A. Treatment of Acute Coronary Ischemia

Chapter 5: Aspirin and Thienopyridines
Chapter 6: Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia
Chapter 7: Clinical Trials in Thrombolytic Therapy
Chapter 8: Clinical Trials of Direct Thrombin Inhibitors
Chapter 9: Glycoprotein IIb/IIIa Receptor Inhibitors
Chapter 10: Adjunctive Medical Therapy for Acute Myocardial Infarction
Chapter 11: Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction
Chapter 12: Coronary Artery Bypass Surgery in Acute Coronary Syndromes

B. Treatment of Arrhythmias

Chapter 13: Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation
Chapter 14: Antiarrhythmic Drug Therapy in Supraventricular Tachycardia
Chapter 15: Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation
Chapter 16: Clinical Trials in Arrhythmia Ablation
Chapter 17: Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation
Chapter 18: Clinical Trials in Pacing

C. Treatment of Congestive Heart Failure

Chapter 19: Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS)
Chapter 20: Beta-blocker Treatment of Heart Failure
Chapter 21: Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure

Section III. PRIMARY AND SECONDARY PREVENTION TRIALS

Chapter 22: Cholesterol Reduction
Chapter 23: Blood Pressure Reduction Treatment Trials
Chapter 24: Prevention Trials of Smoking Cessation
Chapter 25: Physical Activity and Weight Loss
Chapter 26: Aspirin, Other Antiplatelet Agents, and Anticoagulant Agents in the Secondary and Primary Prevention of Cardiovascular Disease
Chapter 27: Postmenopausal Hormone Replacement Therapy
Chapter 28: Antioxidant Vitamins
Chapter 29: Dietary Factors
Chapter 30: Cardiac Psychology/Behavioral Cardiology
Chapter 31: Multiple Risk Factor Intervention Trials
Chapter 32: Prevention Strategies: From the Office to the Community and Beyond