Drug Delivery Systems

Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia. The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections: Site-specific drug delivery Polymers and implantable drug delivery systems Oral drug delivery Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems Regulatory considerations and global outlook Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives.

Contents

Site-Specific Drug Delivery Using Liposomes and Emulsions as Carriers Introduction Liposomes in Drug Delivery The Liposome-Drug Concept Liposomes as Carriers of Therapeutic Agents Parenteral Emulsions Recent Advances and Future Prospects Concluding Remarks References Site-Specific Drug Delivery Utilizing Monoclonal Antibodies Introduction Production of Monoclonal Antibodies Drug--Monoclonal Antibody Conjugates for Drug Targeting Recent Studies with Monoclonal Antibodies Conclusion and Basis for Future Trends References Role of Polymers in Drug Delivery Introduction Currently Available Polymers Soluble Polymers as Drug Carriers Biodegradable or Bioerodible Polymers Mucoadhesive Polymers Polymers Containing Pendant Bioactive Substituents Matrix Systems Heparin-Releasing Polymers Ionic Polymers Oligomers Miscellaneous Recent Advances Conclusion References Implants in Drug Delivery Introduction Insulin Delivery as a Model Implant Pump System Implants for Contraception Delivery of Chemotherapeutic Agents Using Implants Recent Advances in Implants and Related Devices (Excluding Inserts) Future Prospects References Oral Drug Delivery Controlled-Release Formulations Introduction Features of the GI Tract Targeting of Drugs in the GI Tract Mathematical Models for Controlled-Release Kinetics Design and Fabrication of Oral Delivery Systems Survey of Oral Controlled-Release Products Recent Advances Current Development of Oral Drug Delivery Systems Conclusion References Enhancing Oral Bioavailability Introduction Increasing Bioavailability of Water-Insoluble Drugs Increasing Bioavailability of Proteins, Peptides, and Other Drugs with Absorption Problems Recent Advances and Future Prospects References Transdermal Drug Delivery Introduction Theoretical Aspects of Transdermal Drug Delivery Development of the Transdermal Therapeutic System Examples of Transdermal Applications Recent Advances and Future Prospects Conclusion References Transmucosal and Ocular Drug Delivery Introduction: Transmucosal and Ocular Drug Delivery Pulmonary Drug Delivery Intranasal Drug Delivery Buccal and Sublingual Drug Delivery Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery Ocular Drug Delivery Conclusions and Future Outlook for Transmucosal and Ocular Drug Delivery References Miscellaneous Forms of Drug Delivery Introduction Pro-Drugs Infusion Devices Insulin Delivery Recent Advances Summary References Nanoscience and Nanotechnology for Drug Delivery Introduction Nanotechnologies Miscellaneous Applications of Nanomaterials Nanoparticles and Nanostructures Nanomedicine and Nanopharmaceuticals References Regulatory Considerations for Drug Delivery Systems Introduction Current Status of Drug Delivery Technology Submission of Documents for Manufacture and Quality References Drug Delivery Industry and the Global Outlook Basis for the Recent Trend References