Dubois' Lupus Erythematosus

Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition. More than ninety distinguished contributing authors--twenty of them new to this edition--provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Table Of Contents

HISTORY AND DEFINITIONS: Historical Background of Discoid & Systemic Lupus Erythematosus / Definition & Classification of Systemic Lupus Erythematosus / Environmental Aspects of Lupus / Epidemiology of Systemic Lupus Erythematosus

PATHOGENESIS: Pathogenesis of Systemic Lupus Erythematosus / Genetics of Human Lupus / Genetics of Murine Systemic Lupus Erythematosus / Apoptosis / Interaction of T Cells with Cells of the Innate Immune System & B Cells in the Pathogenesis of SLE / Cytokines & Interferons in Lupus / B Cells in Systemic Lupus Erythematosus / Abnormalities in Immune Complex Clearance & Fcγ Receptor Function / Complement & Systemic Lupus Erythematosus / Mechanisms of Acute Inflammation & Vascular Injury in Systemic Lupus Erythematosus / Idiotypes & Idiotype Networks / The Importance of Sex Hormones in Systemic Lupus Erythematosus / Neuroendocrine Immune Interactions: Principles & Relevance to Systemic Lupus Erythematosus / Animal Models of Systemic Lupus Erythematosus / Pathogenesis of Atherosclerosis in Lupus / Autoantigens & Defects in Immune Tolerance in Lupus

AUTOANTIBODIES: Structure & Derivation of Antibodies & Autoantibodies / Antinuclear Antibodies: An Overview / Antibodies to DNA / Antibodies to Histones & Nucleosome-Related Antigens / Antibodies to Ro/SSA & La/SSB / Antibodies to Spliceosomal Components / The Lupus Anticoagulant & Antiphospholipid Antibodies / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus

THE SKIN IN LUPUS: Pathomechanisms of Cutaneous Lupus Erythematosus / Lupus-Specific Skin Disease (Cutaneous LE) / Lupus-Nonspecific Skin Disease

CLINICAL ASPECTS OF LUPUS: Clinical Presentation of Systemic Lupus Erythematosus / The Musculoskeletal System / Cardiovascular Manifestations of Lupus / Pulmonary Manifestations of Systemic Lupus Erythematosus / Clinical Aspects of Vasculitis & Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus / The Nervous System / Psychopathology of Lupus & Neuroimaging / Head & Neck Findings in Systemic Lupus Erythematosus: Manifestations Involving the Eye, Ear & Larynx / Ocular, Aural & Oral Manifestations / Hematologic & Lymphoid Abnormalities in Systemic Lupus Erythematosus / Gastrointestinal & Hepatic Manifestations / Systemic Lupus Erythematosus in Childhood & Adolescence / Drug-Induced Lupus / Infections in Systemic Lupus Erythematosus / Serum & Plasma Protein Abnormalities & Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus / Clinical Indices in the Assessment of Lupus / Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus / Differential Diagnosis & Disease Associations / Mixed Connective Tissue Disease & Overlap Syndromes / The Mother in Systemic Lupus Erythematosus / The Fetus in Systemic Lupus Erythematosus / Neonatal Lupus / Reproductive Issues in Women with Autoimmune Disease / Lupus Nephritis: Pathology & Pathogenesis / Clinical & Laboratory Features of Lupus Nephritis

MANAGEMENT OF LUPUS: Principles of Therapy & Local Measures / Nonsteroidals & Salicylates for Systemic Lupus Erythematosus / Antimalarial Therapies / Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus / Immunosuppressive Drug Therapy / Nonpharmacologic & Complementary Therapeutic Modalities / Fibromyalgia in SLE & Use of Complementary & Alternative Medicine in SLE / Hormones & Gender-Related Issues / Clinical & Management Aspects of the Antiphospholipid Antibody Syndrome / Additional Therapies Used in the Management of Lupus / Adjunctive Measures & Issues: Allergies, Antibiotics, Vaccines & Disability / Issues in Drug Development in SLE: Clinical Trial Design, Outcome Measures & Biomarkers / Prognosis, Mortality & Morbidity in Systemic Lupus Erythematosus / Biologics & Stem Cell Therapies for Lupus

Appendix I. A Patient's Guide to Lupus Erythematosus
Appendix II. Lupus Resources