Fibrinolytic and Antithrombotic Therapy, Theory, Practice, and Management

Reviews

* 'This pocket-sized book is full of integrated insights into hemostasis and vital information on fibrinolytic and antithrombotic therapy. The author writes in easy-to-understand language and supplements his text with appropriately placed figures, graphs, tables, EKGs, and algorithms tailored to the needs of practicing clinicians, cardiologists, emergency room physicians, hematologists, and nurses.' - Doody's Reviews


Description
Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on management guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, haematologists, neurologists, intensivists, pharmacists, and nurse practitioners.

The origins of mammalian blood coagulation can be traced back over 400 million years. Despite its long history, it is only within the past century that this complex and pivotal teleologic system has begun to be understood. Most recently, the intricacies of haemostasis and pathologic thrombosis have come to light, leading the way toward new, more effective, and safer treatment modalities.

The Second Edition of Fibrinolytic and Antithrombotic Therapy, even more concise and clinically relevant than the First, provides vital, evidence-based information on management of patients with arterial and venous thrombotic disorders. Since the First Edition, the text has been expanded to cover the evolving topics of atherothrombosis, thrombocardiology, haematologic/thrombophilic conditions, and vascular medicine. It includes up-to-date guidelines for antithrombotic and fibrinolytic therapy, and offers concise summaries of current "standards of care." Chapters are dedicated to discussions of patient-specific therapeutics and to the importance of genomics, proteomics, and metabolomics in defining genotype-phenotype relationships, while throughout the book coagulation, inflammation, and vascular medicine are newly examined as elements in an intricately-linked triad of biochemical and cellular based phenomenology.

Contents
Part I: Fundamental Scientific Principles
1. Historical Perspectives of Hemostasis, Coagulation, and Fibrinolysis
2. Vascular Biology, Thromboresistance and Inflammation
3. Atherosclerosis and Arterial Thrombosis
4. Venous Thromboembolism
5. Cardiac Chamber, Aortic and Valvular Thromboembolism
Part II: Fibrinolytics and Platelet Antagonists
6. Fibrinolytic Agents
7. Asprin
8. Clopidogrel
9. GPIIb/IIIa Receptor Antagonists
10. Aggrenox and Cilostazol
11. Novel Platelet Antagonists
12. Combination Pharmacotherapy
13. Facilitated Percutaneous Coronary Interventions
Part III: Anticoagulants
14. Thrombin-Directed Therapy
15. Factor Xa Inhibitors
16. Direct Thrombin Inhibitors
17. Novel Anticoagulants
Part IV: Management of Arterial Thrombotic Disorders
18. Acute Coronary Syndromes
19. Peripheral Vascular Disease and Stroke
20. Valvular Heart Disease and Atrial Fibrillation
21. Plaque Stabilizing Therapies
Part V: Management of Venous Thrombotic Disorders
22. Venous Thromboembolism Prophylaxis
23. Venous Thromboembolism Treatment
Part VI: Genomics, Proteomics and Suspected Thrombophilias
24. Fundamentals and Patient Evaluation
Part VII: Monitoring Antithrombotic Therapy
25. Platelet Antagonists
26. Antocoagulants
27. Anticoagulation Clinics and Self-Testing
Part VIII: Complication of Treatment and Their Management
28. Platelet Antagonists
29. Anticoagulants
30. Fibrinolytic Agents
Appendix
A. Pharmacopeia
Platelet Antagonists
Fibrinolytic Agents
B. Drug Dosing with Renal Insufficiency

Authors, editors, and contributors


Richard C. Becker, Professor of Medicine, Duke University Medical Center and
Frederick A. Spencer, Professor of Medicine in Cardiology and Hematology, McMaster University Faculty of Health Sciences