Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs

I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!’

From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA

• Written by a top international editorial team
• Extensively updated to include new, existing and emerging drugs
• Divided into 4 sections, 258 chapters and presented in 2-volumes
• Presented and packaged in 2-volumes plus an e-book

Kucers’ The Use of Antibiotics is the leading major reference work in this vast and
rapidly developing field. More than doubled in length compared to the fifth edition, the
sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing
therapies, and emerging drugs not yet fully licensed.

Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs,anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title.

Compiled by an expanded team of internationally renowned and respected editors, with
a vast number of contributors spanning Europe, Africa, Asia, Australia, South America,
the US and Canada, the sixth edition adopts a truly global approach. It will remain
invaluable for anyone using antimicrobial agents in their clinical practice and provides in
a systematic and concise manner all the information required when treating infections
requiring antimicrobial therapy.

Now Kucers’ The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop:

• It provides access to the entire 2-volume print material
• It is fully searchable, so you can find the relevant information you need quickly
• Live references are linked to PubMed referring you to the latest journal material
• Customise the contents – you can highlight sections and make notes
• Comments can be shared with colleagues/tutors for discussion, teaching and learning
• The text can also be reflowed for ease of reading
• Text and illustrations copied will be automatically referenced to Kucers’ The Use of Antibiotics

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THE essential reference to this vast, and rapidly developing field
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Highly structured for ease of reference
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Covers more than 350 individal antimicrobial agents, more than twice as many as the preceding edition
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International team of highly respected authors and editors ensures a truly global approach


Table of Contents:
ANTIBIOTICS
PART 1 - Penicillins and Related Drugs
Benzylpenicillin (Penicillin G)
Phenoxypenicillins
Ampicillin, Amoxicillin and other Ampicillin-like penicillins
Methicillin
Isoxazolyl penicillins: Oxacillin, cloxacillin, dicloxacillin & flucloxacillin
Nafcillin
Carbenicillin, Carindacillin, Carfecillin & Ticarcillin
Mezlocillin, Azlocillin, Apalcillin & Piperacillin
Mecillinam (Amdinocillin) & Pivmecillinam
Temocillin
Beta-lactamase inhibitors and combinations:
Clavulanic Acid
Sulbactam
Tazobactam and Brobactam
Co-amoxiclav (amoxycillin-clavulanic acid)
Ampicillin-sulbactam
Ticarcillin-clavulanic acid
Piperacillin-tazobactam
PART 2 - Cephalosporins and Related Drugs n=18
Cephalothin and Cefazolin
Cephalexin
Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine and other rarely used first-generation cephalosporins
Cefaclor, cefprozil and loracarbef
Cefuroxime
Cefotiam, Cefuzonam, Cefamandole, Cefonicid and Ceforanide
Cefoxitin, cefotetan and other cephamycins (cefmetazole and flomoxef)
Cefoperazone and cefoperazone-sulbactam
Cefotaxime
Ceftriaxone
Ceftizoxime, cefdinir, cefditoren, cefpodoxime, ceftibuten, cefsulodin and cefpiramide
Cefixime
Ceftazidime
Cefpirome
Cefepime
Ceftaroline
Ceftobiprole
Aztreonam
PART 3 – Carbapenems n=9
Imipenem
Meropenem
Doripenem
Ertapenem
Biapenem
Faropenem
Panipenem
Ritapenem
Sulopenem
PART 4 - Glycopeptides and Lipopeptides
Vancomycin
Teicoplanin
Daptomycin
Oritavancin
Dalbavancin
Telavancin
Ramoplanin
PART 5 - Aminoglycosides
Kanamycin
Gentamicin
Tobramycin
Amikacin
Sisomicin and Netilmicin
Isepamicin
Neomycin
PART 6 – Macrolides and Ketolides
Erythromycin
Roxithromycin
Clarithromycin
Azithromycin
Josamycin and Rosaramicin
Telithromycin
Cethromycin
PART 7 – Tetracyclines and related drugs
Tetracycline
Doxycycline
Minocycline
Tigecycline
PART 8 – Other antibiotics
Linezolid
Quinupristin-dalfopristin
Pristinamycin
Fosfomycin
Fusidic acid (Fusidate sodium)
Polymyxins and Colistin
Novobiocin
Bacitracin and Gramicidin
Mupirocin
Clindamycin and Lincomycin
Chloramphenicol and Thiamphenicol
Spectinomycin
PART 9 – Anti-folate agents and other synthetic antibacterials
Sulfonamides
Trimethoprim, Co-trimoxazole (Co-T) & related agents
Pyrimethamine
Dapsone
Trimetrexate
Iclaprim
Nitrofurans: Nitrofurazone, Furazolidone & Nitrofurantoin
Methenamine Mandelate & Methenamine Hippurate
PART 10 – Nitroimidazoles
Metronidazole
Tinidazole
PART 11 – Quinolones and fluoroquinolones
Nalidixic Acid & Other Older Quinolones
Ciprofloxacin
Norfloxacin
Ofloxacin
Levofloxacin
Moxifloxacin
Gatifloxacin
Garenoxacin
Gemifloxacin
Sitafloxacin
Enoxacin
Pefloxacin
Sparfloxacin
Lomefloxacin
Rufloxacin
Tosufloxacin
Fleroxacin
Newer, discontinued fluoroquinolones: Temafloxacin, Trovafloxacin, Grepafloxacin and Clinafloxacin
PART 12 – Anti-Tuberculous Drugs
Isoniazid
Ethambutol
Pyrazinamide
Rifampicin (Rifampin)
Rifabutin
Rifaximin
Rifapentine
Streptomycin
Para-aminosalicylic Acid (PAS)
Ethionamide and prothionamide
Thiacetazone
Capreomycin
Cycloserine
Viomycin
ANTI-FUNGAL DRUGS
PART 1 - Polyenes
Amphotericin B (AMB): Deoxycholate & Lipid Formulations
Nystatin
Natamycin (Pimaricin)
PART 2 – Echinocandins, Allylamines and Benzylamine derivatives
Echinocandins – Caspofungin, Anidulafungin & Micafungin
Terbinafine
Butenafine
Naftifine
PART 3 – Systemic Azoles
Ketoconazole
Fluconazole
Itraconazole
Miconazole
Voriconazole
Posaconazole
Ravuconazole
Albaconazole
Isavuconazole
PART 4 – Topical Azoles
Bifonazole
Butoconazole
Clotrimazole
Croconazole
Eberconazole
Econazole
Enilconazole
Fenticonazole
Flutrimazole
Isoconazole
Lanoconazole
Neticonazole
Oxiconazole
Sertaconazole
Sulconazole
Terconazole
Tioconazole
KP-103
PART 5 – Topical agents – Thiocarbamates, Hydroxypyridones and Morpholine
Tolnaftate
Amorolfine
Ciclopirox
Rilopirox
PART 6 – Other antifungal agents and new agents in development
Flucytosine (5-Fluorocytosine; 5-FC)
Griseofulvin
Haloprogin
New agents in development – Nikkomycin Z, CAY-1, Sodarins, Butenolides, Enfungumab, Inositol phosphoceramide synthase inhibitors
ANTI-PARASITIC DRUGS
PART 1 – Anti-malarial agents
Chloroquine
Amodiaquine
Quinine and quinidine
Mefloquine
Halofantrine
Lumefantrine
Primaquine
Piperaquine
Tafenoquine
Atovaquone
Proguanil & chloroproguanil
Artemisinins
PART 2 - Agents active against Intestinal and Intra-abdominal Protozoa
Iodoquinol & Quinacrine
Fumagillin
Furazolidone (Furazolidine)
Diloxanide furoate
Spiramycin
Nitazoxanide
Paromomycin
PART 3 - Agents active against American Trypanosomiasis
Benznidazole
Nifurtimox
PART 4 - Agents active against African Trypanosomiasis
Suramin
Melarsoprol
Eflornithine
PART 5 – Agents active against leishmania and other pathogens
Pentamidine
Antimonial agents
Miltefosine
PART 6 - Agents active against Helminths
Albendazole
Mebendazole
Thiabendazole
Triclabendazole
Ivermectin
Diethylcarbamazine (DEC)
Pyrantel pamoate
Praziquantel
Oxamniquine
Metrifonate
Niclosamide
PART 7 - Agents active against Ectoparasites
Permethrin
Piperonyl butoxide
Lindane
Malathion
Crotamiton
ANTI-VIRAL DRUGS
PART 1 - Agents active against Herpesviruses
Aciclovir
Valaciclovir
Famciclovir & Penciclovir
Ganciclovir & Valganciclovir
Cidofovir
Vidarabine
Foscarnet
Maribavir
Trifluridine (Trifluorothymidine)
Idoxuridine
Fomivirsen
PART 2 - Agents active against Human Immunodeficiency Virus
2a - Inhibitors of Reverse Transcriptase
Zidovudine
Didanosine
Zalcitabine
Lamivudine
Stavudine (d4T)
Abacavir
Emtricitabine
Tenofovir
Amdoxovir
Apricitabine
2b – Non-Nucleoside Reverse Transcriptase inhibitors (NNRTIs)
Nevirapine
Efavirenz
Delavirdine
Etravirine
Rilpirivine
2c - Inhibitors of HIV Protease
Saquinavir
Ritonavir
Indinavir
Nelfinavir
Lopinavir
Amprenavir and fosamprenavir
Darunavir
Atazanavir
Tipranavir
2d - Other Anti-HIV Agents
Enfuvirtide
Maraviroc
Raltegravir & other HIV integrase inibitors
Part 3 - Agents active against Hepatitis viruses
Entecavir
Adefovir dipivoxil
Telbivudine
Torcitabine & Valtorcitabine
Clevudine
Ribavirin & Viramidine
Pegylated Interferon Alfa
Protease and polymerase inhibitors for the treatment of hepatitis C virus infection
Part 4 - Agents active against Respiratory viruses
Amantadine & Rimantadine
Zanamivir and Polymeric Zanamivir Conjugates
Oseltamivir
Peramivir