Langman's Medical Embryology

Widely acclaimed for its scientific authority, pedagogy, clinical relevance, and clear, concise writing, this classic text covers all aspects of embryology of interest to medical, nursing, and health professions students. It features outstanding full-color illustrations and clinical images and photographs, end-of-chapter summaries and Problems to Solve, and Clinical Correlates boxes that provide information on birth defects and other clinical entities directly related to embryologic concepts.

This Eleventh Edition has additional images in the birth defects chapters, many new full-color clinical photographs, and recolorized drawings. Other highlights include a glossary, new and updated Problems to Solve, and updated molecular genetics information.

A companion Website will include the fully searchable text, interactive review questions and problems, updated Simbryo animations of embryologic system development, and PowerPoint slides for instructors.

Contents

P A R T O N E
General Embryology
CHAPTER 1 Embryology: Old and New
Frontiers and an Introduction to
Molecular Regulation and Signaling, 3
Clinical Relevance, 3
A Brief History of Embryology, 4
Introduction to Molecular Regulation and
Signaling, 5
CHAPTER 2 Gametogenesis: Conversion of
Germ Cells Into Male and Female
Gametes, 13
Primordial Germ Cells, 13
Clinical Correlates, 13
The Chromosome Theory of Inheritance, 14
Clinical Correlates, 16
Morphological Changes During Maturation of
the Gametes, 24
Clinical Correlates, 30
CHAPTER 3 First Week of Development:
Ovulation to Implantation, 33
Ovarian Cycle, 33
Clinical Correlates, 33
Fertilization, 36
Clinical Correlates, 40
Cleavage, 41
Blastocyst Formation, 41
Clinical Correlates, 43
Uterus at Time of Implantation, 43
CHAPTER 4 Second Week of
Development: Bilaminar Germ Disc, 47
Day 8, 47
Day 9, 47
Days 11 and 12, 48
Day 13, 50
Clinical Correlates, 51
CHAPTER 5 Third Week of Development:
Trilaminar Germ Disc, 55
Gastrulation: Formation of Embryonic Mesoderm
and Endoderm, 55
Formation of the Notochord, 55
Establishment of the Body Axes, 56
Fate Map Established During Gastrulation, 61
Growth of the Embryonic Disc, 61
Clinical Correlates, 61
Further Development of the Trophoblast, 63
CHAPTER 6 Third to Eighth Weeks: The
Embryonic Period, 67
Derivatives of the Ectodermal Germ Layer, 67
Clinical Correlates, 73
Derivatives of the Mesodermal Germ Layer, 74
Clinical Correlates, 81
Derivatives of the Endodermal Germ Layer, 82
Patterning of the Anteroposterior Axis:
Regulation by Homeobox Genes, 84
External Appearance During the Second Month, 85
Clinical Correlates, 87
CHAPTER 7 Third Month to Birth: The
Fetus and Placenta, 91
Development of the Fetus, 91
Clinical Correlates, 95
Fetal Membranes and Placenta, 95
Clinical Correlates, 97
Structure of the Placenta, 100
Clinical Correlates, 102
Clinical Correlates, 103
Amnion and Umbilical Cord, 104
Clinical Correlates, 105
Placental Changes at the End of Pregnancy, 105
Amniotic Fluid, 106
Clinical Correlates, 106
Fetal Membranes in Twins, 106
Clinical Correlates, 109
Parturition (Birth), 111
Clinical Correlates, 111
CHAPTER 8 Birth Defects and Prenatal
Diagnosis, 113
Birth Defects, 113
Clinical Correlates, 120
Prenatal Diagnosis, 121
Fetal Therapy, 123
P A R T T W O
Systems-Based Embryology
CHAPTER 9 Skeletal System, 127
Skull, 127
Clinical Correlates, 131
Viscerocranium, 129
Clinical Correlates, 140
Limbs, 134
Clinical Correlates, 144
Vertebrae and the Vertebral Column, 142
Clinical Correlates, 145
Ribs and Sternum, 144
C O N T E N T S
ix