Malignant Liver Tumors: Current and Emerging Therapies

This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy.

Building on the success of the previous edition, this extremely thorough revision:

* features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines
* reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population
* achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer
* includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies
* facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies

In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.

Contributors.

Preface.

Acknowledgments.

Abbreviations.

Section 1 Introduction.

1 From Promethean to Modern Times (Kuno Lehmann, Stefan Breitenstein, and Pierre-Alain Clavien).

2 Hepatic Anatomy and Terminology (Steven M. Strasberg).

Section 2 Epidemiology and Diagnosis.

Introduction (Chung-Mau Lo).

3 Histology and Pathology of Normal and Diseased Liver (Valérie Paradis and Achim Weber).

4 Pathology of Primary and Secondary Malignant Liver Tumors (Kay Washington).

5 Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma (Wei-Chen Lee and Miin-Fu Chen).

6 Epidemiology, Etiology, and Natural History of Cholangiocarcinoma (Peter Neuhaus, Ulf P. Neumann, and Daniel Seehofer).

7 Epidemiology, Etiology, and Natural History of Colorectal Liver Metastases (Robert J. Porte).

8 Tumor Markers in Primary and Secondary Liver Tumors (Ketsia B. Pierre and Ravi S. Chari).

9 Modalities for Imaging Liver Tumors (Dominik Weishaupt and Thomas F. Hany).

Section 3 Systemic and Regional Therapies.

Introduction (Ravi S. Chari).

10 Systemic Treatment of Hepatobiliary Tumors (Panagiotis Samaras, Michael A. Morse, and Bernhard C. Pestalozzi).

11 External Beam Radiation Therapy for Liver Tumors (Rakesh Reddy and A. Bapsi Chakravarthy).

12 Internal Radiation Therapy for Liver Tumors (Ahsun Riaz, Laura Kulik, Michael Abecassis, and Riad Salem).

13 Transarterial Embolization for Patients with Hepatocellular Carcinoma (Jordi Bruix, Carmen Ayuso, and Maria I. Real).

14 Selective Continuous Intra-arterial Chemotherapy for Liver Tumors (Fidel D. Huitzil-Melendez, Stefan Breitenstein, and Nancy Kemeny).

15 Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion (Charles K. Heller, III, James F. Pingpank, and Steven K. Libutti).

Section 4 Resection, Ablation or Transplantation for Liver Tumors.

Introduction (Jean-Nicolas Vauthey and Tadatoshi Takayama).

16 Liver Resection of Primary Tumors: Hepatocellular Carcinoma, Cholangiocarcinoma, and Gallbladder Cancer (Tadatoshi Takayama and Masatoshi Makuuchi).

17 Liver Resection of Colorectal Liver Metastases (Daria Zorzi, Yun Shin Chun, and Jean-Nicolas Vauthey).

18 Laparoscopic Liver Resection (Luca Viganò and Daniel Cherqui).

19 Repeat Resection for Liver Tumors (Mickael Lesurtel and Henrik Petrowsky).

20 Cryoablation of Liver Tumors (Sivakumar Gananadha and David L. Morris).

21 Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy (M. B. Majella Doyle and David C. Linehan).

22 Ethanol and Other Percutaneous Injection Modalities in the Treatment of Liver Tumors (Michael A. Heneghan and Andrew D. Yeoman).

23 Transplantation for Liver Tumors (François Durand, Claire Francoz, and Jacques Belghiti).

24 Preventing Recurrence of Hepatocellular Carcinoma after Curative Resection (Stefan Breitenstein, Dimitris Dimitroulis, and Beat Müllhaupt).

Section 5 Guidelines for Liver Tumor Treatment.

Introduction (Stefan Breitenstein and Pierre-Alain Clavien).

25 Strategies for Safer Liver Surgery (Philipp Dutkowski, Olivier de Rougemont, and Pierre-Alain Clavien).

26 Hepatocellular Carcinoma (Tadatoshi Takayama).

27 Cholangiocarcinoma (Jacques Belghiti and Charles B. Rosen).

28 Gallbladder Cancer (Juan Hepp and Chung-Mau Lo).

29 Colorectal Liver Metastases (Phuong L. Doan, Jean-Nicolas Vauthey, Martin Palavecino, and Michael A. Morse).

Section 6 Emerging Therapies.

Introduction (Michael A. Morse and Josep M. Llovet).

30 Viral-Based Therapies for Primary and Secondary Liver Cancer (Menghua Dai, Lorena Gonzalez, and Yuman Fong).

31 Signaling Pathways and Rationale for Molecular Therapies in Hepatocellular Carcinoma (Augusto Villanueva, Clara Alsinet, and Josep M. Llovet).

32 Novel Therapies Targeted at Signal Transduction in Liver Tumors, (Fidel D. Huitzil-Melendez, Ghassan K. Abou-Alfa, and Michael A. Morse).

33 Induction of Apoptosis in Liver Tumors (Markus Selzner and Pierre-Alain Clavien).

34 Antiangiogenic Agents for Liver Tumors (Mathijs Vogten, Emile E. Voest, and Inne H.M. Borel Rinkes).

35 Integrative Oncology: Alternative and Complementary Treatments (Barrie R. Cassileth and Jyothirmai Gubili).

Section 7 Special Tumors, Population, and Special Considerations.

Introduction (Stefan Breitenstein and Pierre-Alain Clavien).

36 Liver Metastases from Endocrine Tumors (Clayton D. Knox and C. Wright Pinson).

37 Uncommon Primary and Metastatic Liver Tumors (Stefan Breitenstein, Ashraf Mohammad El-Badry, and Pierre-Alain Clavien).

38 Liver Tumors in Special Populations (Tadahiro Uemura, Akhtar Khan, and Zakiyah Kadry).

39 Malignant Liver Tumors in Children (Xavier Rogiers and Ruth De Bruyne).

40 Liver Tumors in Asia (Norihiro Kokudo, Sumihito Tamura, and Masatoshi Makuuchi).

41 Liver Tumors in South America (Lucas McCormack and Eduardo de Santibañes).

42 Liver Tumors in Africa (Michael C. Kew).

43 Anesthetic Management of Liver Surgery (Marco P. Zalunardo).

44 Qualitative and Economic Aspects of Liver Surgery (René Vonlanthen, Ksenija Slankamenac, and Christian Ernst).

Index.