OSTEOPOROSIS, 2 vol. set

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

Audience
Academic and medical libraries as well as professionals in bone biology, endocrinology, osteology, neuroendocrinology; drug companies developing osteoporosis medications

Contents


Introduction
The Bone Organ System: Form and Function The Nature of Osteoporosis The Economics of Osteoporosis Reflections on Osteoporosis Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis

Basic Science/Bone Biology
Osteoblast Biology Osteoclast Biology Osteocytes The Regulatory Role of Matrix Proteins in Mineralization of Bone Development of the Skeleton Mouse Genetics as a Tool to Study Bone Development and Physiology Parathyroid Hormone and Parathyroid Hormone-Related Protein Vitamin D: Biology, Action, and Clinical Implications Regulation of Bone Cell Function by Estrogens Androgens and Skeletal Biology: Basic Mechanisms Phosphatonins Wnt Signaling in Bone Cytokines and Bone Remodeling Skeletal Growth Factors Intercellular Communication During Bone Remodeling

Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth, Aging and Disease Inhibition of Osteoporosis by Biophysical Intervention Biomechanics of Age-Related Fractures Bone Quality

Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis Race, Ethnicity and Osteoporosis The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions Bone Mineral Acquisition in Utero and During Infancy and Childhood Bone Acquisition in Adolescence Genetic Determinants of Osteoporosis Nutrition and Risk for Osteoporosis Physical Activity in Prevention of Osteoporosis and Associated Fractures Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis Non-Skeletal Risk Factors for Osteoporosis and Fractures Falls as Risk Factors for Fracture Assessment of Fracture Risk Outcomes of Osteoporotic Fractures

Pathophysiology
Local and Systemic Factors in the Pathogenesis of Osteoporosis Animal Models for Osteoporosis Estrogen, Bone Homeostasis and Osteoporosis Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization Osteoporosis in Childhood and Adolescence Glucocorticoid-Induced Osteoporosis Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach Mechanisms of Immobilization-induced Bone Loss Leptin-Dependent Regulation of Bone Mass Thyroid Hormone and the Skeleton Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis Osteoporosis Associated with Illnesses and Medications Transplantation Osteoporosis Osteoporosis Associated with Cancer Therapy Osteoporosis Associated with Pregnancy Osteoporosis Associated with Rheumatologic Disease Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks Localized Osteoporosis

Evaluation and Management
Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis Who Should be Screened: Who Should be Treated? Radiology of Osteoporosis Clinical Use of Bone Densitometry Biochemical Markers of Bone Turnover in Osteoporosis The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis An Orthopedic Perspective of Osteoporosis Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs

Pharmacology and Therapeutics
Design Considerations for Clinical Investigations of Osteoporosis Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials Evidence-Based Osteoporosis Care The Role of Calcium in the Treatment of Osteoporosis Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis Estrogen Therapy: Prevention and Treatment of Osteoporosis Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis Calcitonin in Osteoporosis Strontium Therapy for Osteoporosis Androgens Treatment with PTH Peptides Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis New approaches to Osteoporosis Therapeutics

Volumes

1-2: Osteoporosis, Two-Volume Set, 1-2