Pediatric Endocrinology (Mechanisms, Manifestations and Management)

Written by distinguished authorities, this volume is a comprehensive text on the mechanisms, diagnosis, and management of pediatric endocrine disorders. It provides exceptional coverage of current scientific concepts and state-of-the-art, practical clinical information.

The opening sections examine genetic aspects of endocrinology and diagnostic tests, including imaging and molecular techniques. Subsequent sections cover the hypothalamus and pituitary, growth, sexual differentiation and maturation, glucose homeostasis, the thyroid, the adrenal glands, bone and mineral metabolism, abnormalities of nutrition, and multi-endocrine diseases.

Each section progresses from molecular genetics and developmental endocrinology to specific clinical disorders and management strategies. Numerous illustrations highlight key concepts.

FEATURES:

* Addresses the mechanisms of pediatric endocrine disorders

* Addresses the diagnostic evaluation of children & adolescent w/endocrine disorders

* Consistent approach to topics, progressing from molecular development and genetics to diagnosis and management

Contents

Section I. Genetics in Endocrinology
Chapter 1 Monogenic and Polygenic Disorders in Endocrinology John Phillips III and Amy Potter
Chapter 2 Genetic Syndromes with Endocrinopathies Patricia Y. Fechner

Section II. Evaluation of Endocrine Disorders in Children
Chapter 3 Diagnostic Imaging in Pediatric Endocrinology Donald O. Corea, Aslam R. Siddiqui, and Mary K. Edwards-Brown
Chapter 4 Molecular Concepts and Techniques in Endocrinology Constantin Polychronakos and Zubin Punthakee

Section II. Hypothalamus and Pituitary
Chapter 5 Molecular Genetics of Hypothalamic-Pituitary Axis Development Phu V. Tran, Jesse J. Savage, Holly A. Ingraham, and Simon J. Rhodes
Chapter 6 Manifestations of Mutations in Pituitary Transcription Factors and Clinical Disorders of the Anterior Pituitary John S. Parks and Milton R. Brown
Chapter 7 Clinical Disorders of the Posterior Pituitary Gary L. Robertson
Chapter 8 Endocrine Issues in Survivors of Childhood Cancer Thomas Moshang, Jr., and Stuart A. Weinzimer

Section IV. Growth
Chapter 9 Molecular Mutations in the GH-IGF Axis Zvi Laron
Chapter 10 Physiology of the Growth Hormone--IGF Axis Katie Woods and Ron G. Rosenfeld
Chapter 11 Clinical Aspects of Growth and Growth Disorders Robert Rapaport and Deborah A. Bowlby
Chapter 12 Short Stature and Quality of Life: A Review of Assumptions and Evidence David E. Sandberg, Melissa Colsman, and Linda D. Voss
Chapter 13 Turner Syndrome
Chapter 14 Endocrinopathies in Infants Who Are Small for Gestational Age Mireya H. Garcia, Radhika H. Muzumdar, and Paul Saenger

Section V. Sexual Differentiation and Maturation
Chapter 15 Molecular Genetic Control of Sexual Differentiation Mary M. Lee
Chapter 16 Intersex Disorders Mary Pat Gallagher and Sharon E. Oberfield
Chapter 17 Cryptochidism
Chapter 18 Androgens and Behavior: Implications for the Treatment of Children with Disorders of Sexual Differentiation Sheri A. Berenbaum
Chapter 19 Control of the Onset of Puberty J. P. Bourguignon
Chapter 20 Growth Hormone, Sex Steroids and IGF-I: Metabolic Effects in Puberty and Beyond Nelly Mauras
Chapter 21 Precocious Puberty Peter A. Lee and James R. Kerrigan
Chapter 22 Delayed Puberty John C. Achermann
Chapter 23 Gynecomastia Edward O. Reiter and Glenn D. Braunstein
Chapter 24 Hyperandrogenism in Children and Adolescents M. Belen Roldan Martin and Selma Feldman Wichtel
Chapter 25 Endocrine Disruptors and Development of the Reproductive System: A Pediatric Perspective Katharina M. Main, Ewa Rajpert-De Meyts, Jorma Toppari, and Niels E. Skakkebaek

Section VI. Glucose Homeostasis
Chapter 26 Hypoglycemia in Infants and Children Agneta Sunehag and Morey W. Haymond
Chapter 27 Genetics of Type 1 Diabetes Alba Morales, Jin-Xiong She, and Desmond Schatz
Chapter 28 Pathophysiology of Insulin Dependent Diabetes Rosanna Fiallo-Scharer and George S. Eisenbarth
Chapter 29 Management of Type 1 Diabetes Mellitus David W. Cooke and Leslie Plotnick
Chapter 30 Type 2 Diabetes Mellitus in Children and Adolescents Neslihan Gungor, Ingrid Libman, and Silva Arslanian
Chapter 31 Cystic Fibrosis-Related Diabetes Antoinette Moran

Section VII. Thyroid
Chapter 32 Molecular Mechanisms of the Normal and Abnormal Thyroid Gland Guy Van Vliet
Chapter 33 Congenital Hypothyroidism Margaret H. MacGillivray
Chapter 34 Hypothyroidism and Hyperthyroidism in Children Scott A. Rivkees
Chapter 35 Thyroid Nodules and Thyroid Cancer in Children and Adolescents Andrew J. Bauer, R. Michael Tuttle, and Gary L. Francis

Section VIII. Adrenal
Chapter 36 Molecular Development of the Adrenal Gland David H. Geller and Walter L. Miller
Chapter 37 Clinical Adrenal Disorders Allen W. Root and Dorothy I. Shulman
Chapter 38 Congenital Adrenal Hyperplasia Phyllis W. Speiser

Section IX. Bone and Mineral Metabolism
Chapter 39 Abnormalities of Calcium and Parathyroid Hormone
Chapter 40 Hereditary Defects in Vitamin D Metabolism and Function Anthony A. Portale and Walter L. Miller
Chapter 41 Rickets Associated with Hypophosphatemia Morri E. Markowitz
Chapter 42 Pediatric Bone Disorders

Section X. Abnormalities of Nutrition
Chapter 43 Childhood Obesity Robert H. Lustig, Chaluntorn Preeyasombat, and Pedro A. Velasquez-Mieyer
Chapter 44 Adipose Tissue Function and the Genetics of Obesity David G. Segal and Robert V. Considine
Chapter 45 Eating Disorders: Identification, Evaluation and Treatment of Endocrine Disorders Associated with Eating Disorders Margaret J. Blythe and Lee Ann Conard

Section XI. Systemic Endocrinolog
Chapter 46 Syndromes with Multiple Endocrine Abnormalities Constantine A. Stratakis
Chapter 47 Endocrine Aspects of Stress Abby S. Hollander and Louis J. Muglia

Appendices
A. Laboratory Testing in Pediatric Endocrinology Frank B. Diamond, Jr, and Barry B. Bercu
B. Normative Laboratory Results Frank B. Diamond, Jr, and Barry B. Bercu