Pharmaceutical Biotechnology

The field of pharmaceutical biotechnology is a rapidly evolving subject. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for a spectrum of serious diseases such as cancer, viral infections, cardiovascular and hereditary disorders. In addition, we are confronted with new technologies such as polymerasemistry and gene therapy.
This introductory textbook provides extensive coverage on both the basic science and the applications of biotechnology-produced pharmaceuticals with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate pharmacists.

Contents:
1. Molecular Biotechnology Wiel P.M. Hoekstra and Sjef C.M. Smeekens 2. Biophysical and Biochemical Analysis of Recombinant Proteins Structure and Analysis of Proteins Tsutomu Arakawa and John S. Philo 3. Production and Downstream Processing of Biotech Products Farida Kadir and Mic Hamers 4. Formulation of Biotech Products, Including Biopharmaceutical Considerations Daan J.A. Crommelin 5. Pharmacokinetics and Pharmacodynamics of Peptide and Protein Drugs Rene Braeckman 6. Genomics, Proteomics and Additional Biotechnology-Related Techniques Robert D. Sindelar 7. Gene Therapy Abraham Bout 8. Hematopoietic Growth Factors Jeanne Flynn, Augusto J. Salvado and MaryAnn Foote 9. Interferons and Interleukins Joseph Tami 10. Insulin John M. Beals, Mark L. Brader, Michael R. DeFelippis and Paul M. Kovach 11. Growth Hormones Melinda Marian 12. Vaccines Wim Jiskoot, Gideon F.A. Kersten and E. Coen Beuvery 13. Monoclonal Antibody-Based Pharmaceuticals M.A. Van Dijk and G. Vidarsson Appendix A Trastuzumab/Herceptin Daniel L. Combs Appendix B Abciximab/ReoPro Robert Jordan, Lawrence Deckelbaum and Marian Nakada Appendix C Daclizumab/Zenapax and Basiliximab/Simulect David S. Ziska 14. Recombinant Thrombolytic Agents Nishit B. Modi 15. Recombinant Coagulation Factors Nishit B. Modi 16. Recombinant Human Deoxyribonuclease Melinda Maarian and Dominik Sinicropi 17. Follicle-Stimulating Hormone Tom Sam and Marjo Peters 18. Dispensing Biotechnology Products: Handling, Professional Education and Product Information Peggy Piascik and Gary H. Smith 19. Economic Considerations in Medical Biotechnology Eugene M. Kolassa 20. Biotechnology Products in the Pipeline Ronald P. Evens and Robert D. Sindelar