Platelets

Platelets are small cells are of great importance in many proccesses including thrombosis, bleeding, inflammation, the body's defense against infectious agents, and cancer growth and metastasis. Recently there has been a rapid expansion of the knowledge in both basic biology and the clinical approach to platelet-related diseases including disorders of platelet number and function. Novel platelet function tests, drugs, blood bank storage methods and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and definitive resource.

Audience
Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Contents


Foreword:
A History of Ideas About Platelets in Health and Disease

Biology
The Evolution of Mammalian Platelets Megakaryocyte Development and Platelet Formation Platelet Structure Platelet Cytoskeleton Platelet Turnover and Aging Platelet Genomics and Proteomics Platelet Receptors The GPIb-IX-V Complex Integrin IIb3 Thrombin Receptors ADP Receptors P-Selectin Platelet Polymorphisms Platelet Secretion Signal Transduction During the Initiation, Extension, and Perpetuation of Platelet Plug Formation Platelet Thrombus Formation in Flowing Blood Interactions Between Platelets and the Coagulation System Interactions Between Platelets and the Fibrinolytic System Interactions Between Platelets, Leukocytes, and the Endothelium Platelet-Derived Microparticles Platelet Function in the Newborn

Tests of Platelet Function
Platelet Count The Bleeding Time Platelet Aggregation Flow Cytometry Ultegra Rapid Platelet Function Analyzer Platelet Function Analyzer (PFA)-100 Cone and Plate(let) Analyzer Thromboxane Generation Electron Microscopy Other Clinical Tests of Platelet Function Perfusion Chambers Animal Models

The Role of Platelets in Disease
Atherosclerosis and Coronary Artery Disease Ischemic Cerebrovascular Disease Peripheral Vascular Disease Diabetes Mellitus Renal Disease Inflammation Wound Healing Angiogenesis Antimicrobial Host Defense Tumor Growth and Metastasis Alzheimer Disease Psychiatric Disorders

Disorders of Platelet Number and Function
The Clinical Approach to Disorders of Platelet Number and Function Immune Thrombocytopenic Purpura HIV-1-related Thrombocytopenia Heparin-induced Thrombocytopenia Drug-induced Thrombocytopenia Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome Thrombocytopenia in Pregnancy Thrombocytopenia in the Newborn Inherited Thrombocytopenia Pseudothrombocytopenia Thrombocytosis and Essential Thrombocythemia Inherited Disorders of Platelet Function Acquired Disorders of Platelet Function Cardiopulmonary Bypass

Pharmacology: Antiplatelet Therapy
Aspirin GPIIb-IIIa Antagonists Clopidogrel and Ticlopidine Dipyridamole Cilostazol Experimental Antiplatelet Therapy

Pharmacology: Therapy to Increase Platelet Numbers and/or Function
Thrombopoietin Interleukin 11 Desmopressin Factor VIIa

Transfusion Medicine
Platelet Storage and Transfusion Platelet Transfusion in Infants and Children Platelet Substitutes and Novel Methods of Platelet Preservation

Gene Therapy
Gene Therapy for Platelet Disorders