Preneoplasia of the Breast, A New Conceptual Approach to Proliferative Breast Disease

Safe and accurate preoperative diagnosis of breast lesions is crucial to spare patients unnecessary, disfiguring operations. Prenoeoplasia of the Breast covers the clinical, radiological and histological diagnosis of benign proliferative breast disease and precursor lesions of breast cancer. It focuses on a new immunohistochemical method based on an innovative progenitor cell concept of breast epithelium that has been developed by Prof. Boecker, Prof. Schnitt and Prof. Silverstein. This technique can also be used for small samples (percutaneous core biopsy) and offers high specificity, and therefore provides a greater degree of diagnostic security. The practical applicability and interpretation of the technique are integrated into a comprehensive description of all benign and malignant noninvasive proliferative diseases of the breast, including: • Interpretation of histologic samples attained by stereotactic biopsy (including immunohistochemistry) • Comparison of radiologic and pathologic findings • Action to be taken in the case of in-situ malignoma • Treatment of DICS

Table of Contents

Chapter 1: Normal breast
Chapter 2: Fibrocystic change and miscellaneous ";non-neoplastic"; epithelial and stromal lesion
Chapter 3: Metaplastic changes and their neoplastic counterparts
Chapter 4: Percutaneous breast biopsy
Chapter 5: Non-operative breast pathology
Chapter 6: Examination of surgical specimens
Chapter 7: Basic principles of benign proliferative breast disease
Chapter 8: Usual ductal hyperplasia
Chapter 9: Sclerosing adenosis and other forms of adenosis
Chapter 10: Radial scar
Chapter 11: Papilloma
Chapter 12: Tubular adenoma and variants
Chapter 13: Adenoma of the nipple
Chapter 14: Adenomyoepithelial tumors
Chapter 15: Fibroadenoma and phyllodes tumor
Chapter 16: Inflammatory conditions of the breast
Chapter 17: Basic principles of precursor lesions of breast cancer
Chapter 18: Flat epithelial atypia
Chapter 19: Atypical ductal hyperplasia
Chapter 20: Ductal carcinoma in situ
Chapter 21: Lobular neoplasia
Chapter 22: The cytology of preneoplastic disease
Chapter 23: Hormonal and genetic risk factors
Chapter 24: Treatment for patients with ductal carcinoma in situ
Chapter 25: Risk adapted therapy of ductal carcinoma in situ
Chapter 26: Molecular concept of breast carcinogenesis
Chapter 27: EGF receptors in breast tumors