Principles of Biochemistry

Voet, Voet and Pratt's Fundamentals of Biochemistry, 4e addresses the enormous advances in biochemistry, particularly in the areas of structural biology and Bioinformatics by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting complete and balanced coverage that is clearly written and relevant to human health and disease, Fundamentals of Biochemistry, 4e includes new pedagogy and enhanced visuals that provide a pathway for student learning. The authors are careful to present new information such that it links it to existing content, ever mindful that students assimilate new information only in the proper context. The enriched assessment content in WileyPLUS offers students the opportunity to gauge their conceptual understanding and receive immediate feedback to address misconceptions.

PART I INTRODUCTION

1 Life, Cells, and Thermodynamics 1

2 Physical and Chemical Properties of Water 22

PART II BIOMOLECULES

3 Overview of DNA Structure, Function, and Engineering 40

4 Amino Acids: the Building Blocks of Proteins 76

5 Polypeptide Sequences, Analysis, and Evolution 93

6 Protein Structure and Folding 127

7 Physiological Activities of Proteins 176

8 Saccharide Chemistry 217

9 Lipids, Bilayer, and Membranes 241

10 Passive and Active Transport 288

PART III ENZYMES

11 Mechanisms of Enzyme Action 315

12 Properties of Enzymes 355

13 Hormones and Signal Transduction 396

PART IV METABOLISM

14 Bioenergetics 436

15 Glycolysis and the Pentose Phosphate Pathway 472

16 Additional Pathways in Carbohydrate Metabolism 517

17 The Citric Acid Cycle 551

18 Mitochondrial ATP Synthesis 581

19 Photosynthesis 623

20 Synthesis and Degradation of Lipids 657

21 Synthesis and Degradation of Amino Acids 712

22 Regulation of Fuel Metabolism 767

PART V GENE EXPRESSION AND REPLICATION

23 Nucleotide Synthesis and Degradation 793

24 DNA Structure and Interactions with Proteins 821

25 DNA Synthesis and Repair 867

26 RNA Metabolism 919

27 The Genetic Code and Translation 962

28 Gene Expression in Prokaryotes and Eukaryotes 1013

Solutions to Odd-Numbered Problems SP-1

Glossary G-1

Index I-1