Transfusion Medicine and Hemostasis, Clinical and Laboratory Aspects

Residents and fellows in hematology, transfusion medicine, pathology, and anesthesiology; practicing physicians in hematology, transfusion medicine, pathology, and anethesiology.
Description

This new handbook in transfusion medicine and hemostasis aims to combine clinical and laboratory information from two fields which have high degrees of overlap into one concise, easy-to-use pocket book. This comprehensive reference guide will have the depth of information to be helpful to all physicians who order and administer blood components and specialized factors for hemostatic abnormalities, as well as those who consult and care for these often very ill patients. The breadth of the book will be ideal for pathology, transfusion medicine, hematology, and anesthesiology residents and fellows, as well as certified and specialized practitioners in these fields.

The editors have chosen to employ a standardized format throughout the book which allows each chapter to be focused on a well-defined subject consisting of less than 6 pages. Information should be easy to read, precise, and concise. Though extensive reference lists are valuable in larger texts, they are not necessary in a pocket-size handbook intended for quick reference. The editors have chosen to include key, recent publications as ?Further Readings?, most often from the past 2 years. A general reference list to larger textbooks and standards in the fields will be included at the end along with a list of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities.

Table of Contents

TABLE OF CONTENTS: I. Blood Banking and Transfusion Medicine A. Introduction 1. BLOOD BANKING AND TRANSFUSION MEDICINE – THE FIELD, THE DISCIPLINE AND THE INDUSTRY CHRISTOPHER D. HILLYER, MD 2. A BRIEF HISTORY OF BLOOD TRANSFUSION ALFRED J. GRINDON, MD 3. INTRODUCTION TO QUALITY SYSTEMS and QUALITY MANAGEMENT JIMMIE L. EVANS AND CHRISTOPHER D. HILLYER, MD B. Blood Banking 4. THE ROLE OF THE PHYSICIAN IN THE BLOOD CENTER CHRISTOPHER D. HILLYER, MD a. Donation process 5. BLOOD DONOR, DONATION PROCESS AND TECHNICAL ASPECTS OF BLOOD COLLECTION KRISTA L. HILLYER, MD 6. APHERESIS BLOOD COMPONENT COLLECTIONS KRISTA L. HILLYER, MD 7. RECIPIENT-SPECIFIC BLOOD DONATION KRISTA L. HILLYER, MD 8. ADVERSE DONOR REACTIONS KRISTA L. HILLYER, MD b. Component manufacturing 9. COMPONENT PREPARATION AND MANUFACTURING COURTNEY E. GREENE AND CHRISTOPHER D. HILLYER, MD c. Donor testing 10. SEROLOGIC TESTING OF DONOR PRODUCTS KRISTA L. HILLYER, MD 11. OVERVIEW OF INFECTIOUS DISEASE TESTING CHRISTOPHER D. HILLYER, MD 12. HIV SCREENING OF DONOR PRODUCTS KRISTA L. HILLYER, MD 13. HEPATITIS B SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 14. HEPATITIS C SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 15. WNV SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 16. SYPHILIS, HTLV, AND CHAGAS TESTING OF DONOR PRODUCT CHELSEA A. SHEPPARD, MD AND KRISTA L. HILLYER, MD 17. BACTERIAL DETECTION METHODS BETH H. SHAZ, MD C. Transfusion Medicine 18. THE ROLE OF THE TRANSFUSION SERVICE PHYSICIAN BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD a. Testing 19. PRETRANSFUSION TESTING BETH H. SHAZ, MD 20. ANTIBODY IDENTIFICATION BETH H. SHAZ, MD 21. DIRECT ANTIGLOBULIN TEST BETH H. SHAZ, MD b. Blood groups 22. ABO AND H BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 23. RH BLOOD GROUP SYSTEM BETH H. SHAZ, MD 24. KELL AND KIDD BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 25. MNS AND DUFFY BLOOD GROUP SYSTEMS BETH H. SHAZ, MD JOHN D. ROBACK, MD, PhD 26. LEWIS,I , AND P BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 27. OTHER BLOOD GROUP SYSTEMS, COLLECTIONS, AND ANTIGENS BETH H. SHAZ, MD c. Blood products 28. RED BLOOD CELLS AND RELATED PRODUCTS CHRISTOPHER D. HILLYER, MD 29. PLASMA PRODUCTS CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 30. PLATELET PRODUCTS BETH H. SHAZ, MD 31. CRYOPRECIPITATE BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 32. GRANULOCYTE PRODUCTS CHRISTOPHER D. HILLYER, MD AND LAWRENCE B. FIALCOW, DO 33. ALBUMIN AND RELATED PRODUCTS ANNE M. WINKLER, MD AND BETH H. SHAZ, MD 34. HUMAN IMMUNOGLOBULIN PREPARATIONS BETH H. SHAZ, MD 35. RH IMMUNE GLOBULIN BETH H. SHAZ, MD d.Product modifications 36. IRRADIATION OF BLOOD PRODUCTS BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 37. LEUKOREDUCTION OF BLOOD PRODUCTS JAMES C. ZIMRING, MD, PhD 38. CMV- SAFE BLOOD PRODUCTS JOHN D. ROBACK, MD, PhD 39. FROZEN BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD 40. WASHED BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD 41. VOLUME REDUCED BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD e. Specific clinical settings 42. NEONATAL AND PEDIATRIC TRANSFUSION MEDICINE JEANNE E. HENDRICKSON, MD AND CASSSANDRA D. JOSEPHSON, MD 43. PERINATAL TRANSFUSION MEDICINE BETH H. SHAZ, MD 44. AUTOIMMUNE HEMOLYTIC ANEMIAS BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 45. TRANSFUSION MANAGEMENT IN PATIENTS WITH HEMOGLOBINOPATHIES BETH H. SHAZ, MD 46. TRANSFUSION OF PATIENTS UNDERGOING HPC AND SOLID ORGAN TRANSPLANTATION JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 47. TRANSFUSION OF HIV POSITIVE PATIENTS JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 48. TRANSFUSION MANAGEMENT IN PATIENTS WHO REFUSE BLOOD TRANSFUSION JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 49. PLATELET TRANSFUSION REFRACTORY PATIENTS JEANNE E. HENDRICKSON, MD and JOHN D. ROBACK, MD, PhD 50. MASSIVE TRANSFUSION BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 51. PERIOPERATIVE BLOOD MANAGEMENT BETH H. SHAZ, MD f. Transfusion reactions 52. ADVERSE EVENTS AND OUTCOMES FOLLOWING TRANSFUSION: AN OVERVIEW CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 53. FEBRILE NON-HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 54. ALLERGIC, ANAPHYLACTOID AND ANAPHYLATIC REACTIONS BETH H. SHAZ, MD 55. ACUTE HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 56. DELAYED HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 57. TRANSFUSION ASSOCIATED CIRCULATORY OVERLOAD JEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD 58. TRANSFUSION RELATED ACUTE LUNG INJURY JEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD 59. SEPTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 60. METABOLIC, HYPOTENSIVE AND OTHER ACUTE REACTIONS AND COMPLICATIONS BETH H. SHAZ, MD 61. POST TRANSFUSION PURPURA ALFRED J. GRINDON 62. TRANSFUSION ASSOCIATED GRAFT VERSUS HOST DISEASE BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 63. MICROCHIMERISM BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 64. TRANSFUSION RELATED IMMUNOMODULATION JAMES C. ZIMRING, MD, PhD 65. IRON OVERLOAD CASSSANDRA D. JOSEPHSON, MD 66. TRANSFUSION TRANSMITTED DISEASES BETH H. SHAZ, MD g. Therapeutic apheresis and phlebotomy 67. OVERVIEW TO THERAPEUTIC APHERESIS BETH H. SHAZ, MD 68. THERAPEUTIC PLASMA EXCHANGE BETH H. SHAZ, MD 69. THERAPEUTIC ERYTHROCYTAPHERESIS BETH H. SHAZ, MD 70. THERAPEUTIC THROMBOCYTAPHERESIS BETH H. SHAZ, MD 71. THERAPEUTIC LEUKOCYTAPHERESIS BETH H. SHAZ, MD 72. EXTRACORPOREAL PHOTOPHERESIS MARY DORROW, MD JEANNE E. HENDRICKSON, MD, and JOHN D. ROBACK, MD, PhD 73. LDL APHERESIS BETH H. SHAZ, MD 74. IMMUNOABSORPTION BETH H. SHAZ, MD 75. THERAPEUTIC PHLEBOTOMY LAWRENCE B. FIALCOW, DO and BETH H. SHAZ, MD h. Cellular therapy and tissue banking 76. HPC PRODUCTS JOHN D. ROBACK, MD, PhD and ELLIE HAMILTON 77. TISSUE BANKING in the HOSPITAL SETTING CASSSANDRA D. JOSEPHSON, MD II. Coagulation A. Introduction 78. AN OVERVIEW OF THE COAGULATION SYSTEM THOMAS C. ABSHIRE, MD and SHAWN JOBE, MD, PhD B. Clinical coagulation 79. APPROACH TO THE BLEEDING PATIENT THOMAS C. ABSHIRE, MD a. Neonatal thrombocytopenia 80. CONGENITAL THROMBOCYTOPENIA SHAWN JOBE, MD, PhD 81. NEONATAL ALLOIMMUNE THROMBOCYTOPENIA CAROLYN BENNETT, MD 82. ACQUIRED NEONATAL THROMBOCYTOPENIA CAROLYN BENNETT, MD b. inherited platelet function disorders 83. BERNARD-SOULIER SYNDROME AND OTHER GPIB-IX-V RELATED RECEPTOR DEFECTS SHAWN JOBE, MD, PhD 84. GLANZMANN'S THROMBOCYTOPENIA SHAWN JOBE, MD, PhD 85. PLATELET STORAGE GRANULE DEFECTS SHAWN JOBE, MD, PhD 86. FAILURE TO RELEASE AND ASPIRIN-LIKE DEFECTS SHAWN JOBE, MD, PhD c. Immune thrombocytopenia 87. ACUTE (CHILDHOOD) IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 88. CHRONIC IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 89. DRUG INDUCED THROMBOCYTOPENIA CAROLYN BENNETT, MD 90. HEPARIN INDUCED THROMBOCYTOPENIA CHRISTINE KEMPTON, MD 91. AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME MICHAEL BRIONES, DO d. Immune mediated coagulopathies 92. HEMOLYTIC UREMIC SYNDROME MICHAEL BRIONES, DO 93. THROMBOTIC THROMBOCYTOPENIC PURPURA CHRISTINE KEMPTON, MD 94. ANTIPHOSPHOLIPID ANTIBODY SYNDROME MICHAEL BRIONES, DO e. congenital bleeding disorders 95. VON WILLEBRAND DISEASE THOMAS C. ABSHIRE, MD 96. HEMOPHILIA A AMY DUNN, MD 97. HEMOPHILIA B AMY DUNN, MD 98. CONGENITAL DISORDERS OF FIBRINOGEN SHANNON MEEKS, MD 99. FACTOR XIII, D á2-ANTIPLASMIN, AND PLASMINOGEN ACTIVATOR INHIBITOR-1 DEFICIENCIES SHANNON MEEKS, MD 100. FACTOR XI DEFICIENCY THOMAS C. ABSHIRE, MD 101. FACTOR VII DEFICIENCY SHANNON MEEKS, MD 102. FACTOR II, FACTOR V, AND FACTOR X DEFICIENCIES SHANNON MEEKS, MD f. acquired bleeding disorders 103. BLEEDING DISORDERS IN PREGNANCY CHRISTINE KEMPTON, MD 104. VASCULAR BLEEDING DISORDERS MICHAEL BRIONES, DO 105. BLEEDING RISKS WITH LIVER DISEASE THOMAS C. ABSHIRE, MD 106. BLEEDING RISKS WITH VITAMIN K DEFICIENCY THOMAS C. ABSHIRE, MD 107. BLEEDING RISKS WITH CARDIAC DISEASE THOMAS C. ABSHIRE, MD 108. BLEEDING RISKS WITH RENAL DISEASE THOMAS C. ABSHIRE, MD 109. BLEEDING IN CANCER MICHAEL BRIONES, DO 110. DISSEMINATED INTRAVASCULAR COAGULOPATHY AMY DUNN, MD 111. ACQUIRED COAGULATION FACTOR INHIBITORS CHRISTINE KEMPTON, MD C. Laboratory testing of coagulation a. Introduction 112. INTRODUCTION TO COAGULATION TESTING JAMES C. ZIMRING, MD, PhD b. Screening tests 113. PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME JAMES C. ZIMRING, MD, PhD 114. PLATELET COUNT JAMES C. ZIMRING, MD, PhD 115. GLOBAL TESTS FOR PRIMARY HEMOSTASIS CONNIE H. MILLER Ph.D. c. Laboraty assessment of platelet disorders 116. PLATELET AGGREGATION STUDIES CONNIE H. MILLER Ph.D. 117. LABORATORY DIAGNOSIS OF GENETIC PLATELET FUNCTION DEFECTS CONNIE H. MILLER Ph.D. 118. LABORATORY DIAGNOSIS OF ACQUIRED PLATELET FUNCTION DEFECTS CONNIE H. MILLER Ph.D. 119. LABORATORY DIAGNOSIS IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 120. ADAMTS 13 ASSAYS CHRISTINE KEMPTON, MD 121. LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIA ANNE M. WINKLER, MD AND JAMES C. ZIMRING, MD, PHD d. Laboratoy assessment of VWD 122. MOLECULAR BIOLOGY OF VON WILLEBRAND DISEASE CONNIE H. MILLER Ph.D. 123. DIAGNOSIS OF INHERITED VON WILLEBRAND DISEASE Connie H. Miller Ph.D. 124. LABORATORY DIAGNOSIS OF ACQUIRED VWD CONNIE H. MILLER Ph.D. 125. LABORATORY ASSESSMENT OF TREATMENT OF VWD CONNIE H. MILLER Ph.D. e. Laboratoy assessment of coagulation factor disorders 126. SPECIFIC FACTOR ASSAYS CONNIE H. MILLER Ph.D. 127. MIXING STUDIES CONNIE H. MILLER Ph.D. 128. SPECIFIC FACTOR INHIBITORS Connie H. Miller Ph.D. f. Laboratoy assessment of fibrinogen and fibrinolysis 129. LABORATORY DIAGNOSIS OF DYSFIBRINOGENEMIA AND AFIBRINOGENEMIA THOMAS C. ABSHIRE, MD 130. LABORATORY ASSESSMENT OF FIBRINOLYSIS THOMAS C. ABSHIRE, MD g. Tests for hypercoagulable state 131. GENERAL OVERVIEW OF THE HYPERCOAGULABLE STATE MICHAEL BRIONES, DO 132. ANTITHROMBIN TESTING JAMES C. ZIMRING, MD, PhD 133. PROTEINS C, S, AND Z JAMES C. ZIMRING, MD, PhD 134. ACTIVATED PROTEIN C RESISTANCE AND FACTOR V LEIDEN ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 135. PROTHROMBIN GENE MUTATION ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 136. HYPERHOMOCYSTENEMIA JAMES C. ZIMRING, MD, PhD 137. LUPUS ANTICOAGULANT AND ANTIPHOSPHOLIPID ANTIBODIES MICHAEL BRIONES, DO 138. LIPOPROTEIN (A) ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 139. FACTOR LEVEL ABNORMALITIES ASSOCIATED WITH THROMBOSIS JAMES C. ZIMRING, MD, PhD h. Tests for activation of the coagulation system 140. LABORATORY MANAGEMENT OF DIC THOMAS C. ABSHIRE, MD i. Laboratoy support for anticoagulation 141. HEPARIN MONITORING ANNE WINKLER MD AND JAMES C. ZIMRING, MD, PhD 142. WARFARIN MONITORING ANNE M. WINKLER M.D. D. Coagulation factor products 143. PROTHROMBIN COMPLEX CONCENTRATES CHRISTINE KEMPTON, MD 144. VON WILLEBRAND FACTOR PRODUCTS THOMAS C. ABSHIRE, MD 145. FACTOR VIII CONCENTRATES AMY DUNN, MD 146. FACTOR IX CONCENTRATES AMY DUNN, MD 147. FACTOR VII CONCENTRATE CHRISTINE KEMPTON, MD 148. ANTITHROMBIN PRODUCTS MICHAEL BRIONES, DO 149. PROTEIN C PRODUCTS MICHAEL BRIONES, DO