english version

Genome Editing A Practical Guide to Research and Clinical Applications

Genome Editing
A Practical Guide to Research and Clinical Applications
Preț: 756,00 lei
Disponibilitate: la comandă
ISBN: 9780128234846
Anul publicarii: 2021
Pagini: 220
Categoria: GENETICS


Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research.

  • Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i. e., both research applications and clinical applications
  • Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid
  • Written in an easy-to-follow manner, guiding readers from the design of the project to its completion
  • Includes unpublished and new methods

Table of Contents

1. Basic principles of genome editing
2. Choosing a target site and editing strategy
3. Choosing a nuclease, guide RNA, and repair template
4. Assessing for off-target mutagenesis
5. Assessing the outcomes of genome editing
6. Base editing and other advanced forms of genome editing
7. Epigenome editing
8. Cellular disease modeling and risk prediction
9. Functional experiments and screens
10. Therapeutic applications
11. Ethical implications


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