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Hayes' Principles and Methods of Toxicology

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ISBN: 9781032467085
Editura:
Anul publicarii: 2023
Ediția: 7
Pagini: 2140
Categoria: TOXICOLOGY

DESCRIERE

Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. 

Key Features:

  • The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.
  • Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.
  • All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences
  • New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary.  

The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). 

This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

SECTION I    Principles of Toxicology

Chapter 1    History, Understanding and a Possible Future of Toxicology. Harming and Helping through Time.

Richard W. Lane with revisions and a new section by Anthony D. Dayan 

Chapter 2    Use of Toxicology in the Regulatory Process 

Robyn L. Prueitt, Barbara D. Beck, and Edward J. Calabrese

Chapter 3    The Dose–Response: A Fundamental Concept in Toxicology 

Edward J. Calabrese

Chapter 4    Metabolism: A Determinant of Toxicity 

Tao Wang and Richard Zang

Chapter 5    Toxicokinetics 

Leanne L. Bedard 

Chapter 6    Physiologically Based Pharmacokinetic and Toxicokinetic Models 

Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen

Chapter 7    Toxicopanomics: Applications of Genomics, Transcriptomics,
Proteomics, Metabolomics and Lipidomics in Predictive Mechanistic Toxicology 

Mohamed-Amin Choukrallah, Marja Talikka, Stephanie Boue, Philippe Alexandre Guy, Aditya Reddy Kolli, Sandro Steiner, David Bovard, Diego Marescotti, Oksana Lavrynenko, Catherine Nury, James N. Battey, Bjorn Titz, Ulrike Kogel, Alain Sewer, Nicolas Sierro, Florian Martin, Nikolai V. Ivanov, Manuel C. Peitsch, and Julia Hoeng

Chapter 8     Toxicologic Assessment of Pharmaceutical, Medical Device and Biotechnology Products

Michael A. Dorato, Caitlin J. Murphy, J. Scott Daniels, Erin M. Quist, and C. Steven Godin

Chapter 9    Statistics and Experimental Design for Toxicologists 

Shayne C. Gad

Chapter 10  The Practice of Exposure Assessment 

Dennis J. Paustenbach, Amy K. Madl, and Andrey Massarsky

Chapter 11  Epidemiology for Toxicologists 

Geary W. Olsen, Robert R. Roy, Sarah E. Kleinschmidt, and Ralph R. Cook

Chapter 12  Pathology Principles and Practices for Toxicity Studies

Brad Bolon, Tara Arndt, Adam Aulbach, and Kenneth A. Schafer

Chapter 13  Chemical Toxicology Information Resources

Stephanie Holmgren, Jacqueline Patterson, Kristina Thayer, Philip Wexler, and Antony J. Williams

SECTION II    Agents

Chapter 14  Food Safety and Foodborne Toxicants 

Fleur De Mooij, Yu Janet Zang, Amy L. Roe, and Angelika Tritscher

Chapter 15  Plant and Animal Toxins 

Kevin D. Welch, Glenn F. King, Julian White, Leanne A. Pearson, Brett A. Neilan, and Daniel Cook

Chapter 16  Safety Assessment of Cosmetics and Personal Care Products 

Christina Hickey, Siti Amelia Juraimi, Lauren Hutchison, Anne Marie Api, and Benjamin P.C. Smith

Chapter 17  Solvents and Industrial Hygiene 

John E. Snawder

Chapter 18  Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 

James Bus 

Chapter 19  Metals 

Paul B. Tchounwou, Joseph R. Landolph, Jr., and Janis E. Hulla 

Chapter 20  Radiation Toxicity

Roger O. McClellan

SECTION III    Methods

Chapter 21  The Humane Care and Use of Laboratory Animals in Toxicology Research 

Michael J. Caruso, Tyler C. Plachta, Christopher N. Papagiannis, Zac Lloyd, Dale M. Cooper, and David G. Serota

Chapter 22  Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies 

Nicole Kleinstreuer and David Allen

Chapter 23  Modern Instrumental Methods for Studying Mechanisms of Toxicology

W.M. Coleman, III, Serban C. Moldoveanu, Mehdi Ashraf-Khorassini, and Francis L. Martin

Chapter 24  Acute Toxicity and Eye Irritancy 

Saura C. Sahu and A. Wallace Hayes

Chapter 25  Short-Term, Subchronic, and Chronic Toxicology Studies

Daniel T. Wilson, Jerry F. Hardisty, Torrie A. Crabbs, and Shannon M. Wallace

Chapter 26  Genetic and Epigenetic Toxicology 

Leslie Recio and Tetyana Kobets 

Chapter 27  Carcinogenicity Bioassays and Related Assays; Human Relevance 

Gary M. Williams, Tetyana Kobets, Michael J. Iatropoulos, Thomas Nolte, and Esther Vock 

Chapter 28  Assessment of Behavioral Toxicity 

Deborah A. Cory-Slechta and Marissa Sobolewski 

SECTION IV    Organ- and System-Specific Toxicology

Chapter 29  Dermatotoxicology 

Benjamin B. Hayes and Howard J. Maibach

Chapter 30  Inhalation Toxicology 

John J. Godleski, Sandra A. McDonald, and Lester Kobzik

Chapter 31  Gastrointestinal Toxicology 

Peter Pressman, Roger Clemens, and Robert W. Kapp, Jr.

Chapter 32  Hepatotoxicology 

Maksat Babayev, Luma Melo, and James Klaunig

Chapter 33  Principles and Methods for Renal Toxicology 

Jennifer G. Schnellmann and Rick G. Schnellmann 

Chapter 34  Cardiovascular Toxicology Methods 

Barry Bleske and Matthew J. Campen 

Chapter 35  Neurotoxicology 

Anke M. Tukker, Aaron B. Bowman, Lucio G. Costa, and Michael Aschner

Chapter 36  Toxicology of the Endocrine System

Carr J. Smith, Thomas A. Perfetti, and Judy A. King 

Chapter 37  Assessment of Male Reproductive Toxicity 

Natasha R. Catlin, Jon C. Cook, and Gregg D. Cappon 

Chapter 38  Female Reproductive and Developmental Toxicology 

Stephen B. Harris, Kary E. Thompson, Pragati S. Coder, Eve Mylchreest, Amy Lavin Williams, and John M. DeSesso

Chapter 39  Immunotoxicology. The Immune System Response to Toxic Insult

Florence G. Burleson, Stefanie C.M. Burleson, Gary R. Burleson, and Victor J. Johnson

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