english version

Lanzkowsky's Manual of Pediatric Hematology and Oncology

Lanzkowsky's Manual of Pediatric Hematology and Oncology
Autor:
ISBN: 9780128013687
Anul publicării: 2016
Ediția: 6
Pagini: 788
Format: Hardcover
Categoria: HEMATOLOGY
Preț: 577,50 lei
Disponibilitate: în stoc la furnizor

DESCRIERE

This comprehensive clinical manual provides a concise, systematic approach to the diagnosis and treatment of hematologic and oncologic cancers and disorders in children, and is based on the new standards of genetic classification and prognostic information that have emerged in the past five years
 
  • Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manual
  • Offers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pages
  • Presents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disorders
  • Includes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias

Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Sixth Edition, is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks.

Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).

 

  • Dedication
  • List of Contributors
  • About the Editors
  • Preface to the Sixth Edition
  • Preface to the Fifth Edition
  • Preface to the Fourth Edition
  • Preface to the Third Edition
  • Preface to the Second Edition
  • Preface to the First Edition
  • Introduction: Historic Perspective
    • Reflection on 60 Years of Progress in Pediatric Hematology-Oncology
  • Chapter 1. Diagnostic Molecular and Genomic Methodologies for the Hematologist/Oncologist
    • Abstract
    • Clinical Molecular and Genomic Methodologies
    • Interpreting and Evaluating the Results from Clinical Genetic Testing
    • Further Reading and References
  • Chapter 2. Hematologic Manifestations of Systemic Illness
    • Abstract
    • Hematologic Manifestations of Diseases Related to Various Organs
    • Chronic Illness
    • Lead Intoxication
    • Nutritional Disorders
    • Bone Marrow Infiltration
    • Further Reading and References
  • Chapter 3. Classification and Diagnosis of Anemia in Children
    • Abstract
    • Classification and Diagnosis
    • Further Reading and References
  • Chapter 4. Lymphadenopathy and Diseases of the Spleen
    • Abstract
    • Lymphadenopathy
    • Diseases of the Spleen
    • Splenomegaly
    • Further Reading and References
  • Chapter 5. Anemia During the Neonatal Period
    • Abstract
    • Hemorrhage
    • Hemolytic Anemia
    • Failure of Red Cell Production
    • Anemia of Prematurity
    • Physiologic Anemia
    • Diagnostic Approach to Anemia in the Newborn
    • Further Reading and References
  • Chapter 6. Iron-Deficiency Anemia
    • Abstract
    • Prevalence
    • Etiologic Factors
    • Clinical Features
    • Diagnosis
    • Stages of Iron Depletion
    • Differential Diagnosis
    • Treatment
    • Further Reading and References
  • Chapter 7. Megaloblastic Anemia
    • Abstract
    • Vitamin B12 (Cobalamin) Deficiency
    • Folic Acid Deficiency
    • Clinical Features of Cobalamin and Folate Deficiency
    • Diagnosis of Cobalamin and Folate Deficiency
    • Treatment
    • Further Reading and References
  • Chapter 8. Bone Marrow Failure
    • Abstract
    • Aplastic Anemia
    • Acquired Aplastic Anemia
    • Inherited Bone Marrow Failure Syndromes
    • Fanconi Anemia
    • Dyskeratosis Congenita
    • Congenital Aplastic Anemias of Unknown Inheritance
    • Diamond–Blackfan Anemia (Congenital Pure Red Cell Aplasia)
    • Transient Erythroblastopenia of Childhood
    • Congenital Dyserythropoietic Anemia
    • Sideroblastic Anemias (Mitochondrial Diseases with Bone Marrow Failure Syndromes)
    • Severe Congenital Neutropenia and Kostmann Syndrome
    • Reticular Dysgenesis
    • Further Reading and References
  • Chapter 9. General Considerations of Hemolytic Diseases, Red Cell Membrane, and Enzyme Defects
    • Abstract
    • Clinical Features of Hemolytic Disease
    • Laboratory Findings
    • Membrane Defects
    • Paroxysmal Nocturnal Hemoglobinuria
    • Enzyme Defects
    • Further Reading and References
  • Chapter 10. Extracorpuscular Hemolytic Anemia
    • Abstract
    • Immune Hemolytic Anemia
    • NonImmune Hemolytic Anemia
    • Further Reading and References
  • Chapter 11. Hemoglobinopathies
    • Abstract
    • Sickle Cell Disease
    • Thalassemias
    • Management of the Acutely Ill Thalassemic Patient
    • Further Reading and References
  • Chapter 12. Polycythemia
    • Abstract
    • Polycythemia (Erythrocytosis) in the Newborn
    • Polycythemia in Childhood
    • Polycythemia Vera
    • Primary Familial and Congenital Polycythemia
    • Congenital Polycythemia Due to Altered Hypoxia Sensing with Normal P50
    • Congenital Polycythemia Due to Altered Hypoxia Sensing with Decreased P50
    • Other Causes of Polycythemia
    • Diagnostic Approach
    • Further Reading and References
  • Chapter 13. Disorders of White Blood Cells
    • Abstract
    • Quantitative Disorders of Leukocytes
    • Decreased Production or Intrinsic Defects of Neutrophils
    • Increased Destruction or Extrinsic Defects of Neutrophils
    • Immune Neutropenia
    • NonImmune Neutropenia
    • Eosinophils
    • Lymphocytes
    • Disorders of Leukocyte Function
    • Disorders of Adhesion and Chemotaxis
    • Disorders of Neutrophil Granules
    • Disorders of Oxidative Metabolism
    • Neutrophil Production and Destruction in Newborn Infants
    • Neutrophil Function in the Newborn
    • Further Reading and References
  • Chapter 14. Disorders of Platelets
    • Abstract
    • Thrombocytopenia in the Newborn
    • Inherited Thrombocytopenias
    • Immune Thrombocytopenic Purpura (ITP)
    • Other Causes of Thrombocytopenia
    • Thrombocytosis
    • Qualitative Platelet Disorders
    • Acquired Platelet Disorders
    • Nonthrombocytopenic Purpura
    • Further Reading and References
  • Chapter 15. Disorders of Coagulation
    • Abstract
    • Hemostatic Disorders
    • Hemostasis in the Newborn
    • Detection of Hemostatic Defects
    • Acquired Coagulation Factor Disorders
    • Inherited Coagulation Factor Disorders
    • von Willebrand Disease
    • Rare Coagulation Factor Disorders (FII, V, VII, X, XI, XIII, Fibrinogen Deficiencies)
    • Thrombotic Disorders
    • Venous Thrombosis
    • Arterial Thrombosis
    • Antiphospholipid Antibody Syndrome
    • Hereditary Thrombotic Disorders
    • Thrombotic Disorders in Newborns
    • Antithrombotic Agents
    • Antithrombotic Therapy in Special Conditions
    • Further Reading and References
  • Chapter 16. Lymphoproliferative Disorders
    • Abstract
    • Lymphoproliferative Disorders
    • Further Reading and References
  • Chapter 17. Myelodysplastic Syndromes and Myeloproliferative Disorders
    • Abstract
    • Myelodysplastic Syndromes
    • Juvenile Myelomonocytic Leukemia
    • Myeloproliferative Neoplasms
    • CML, BCR–ABL1 Positive
    • Essential Thrombocythemia and Polycythemia Vera
    • Primary Myelofibrosis
    • Further Reading and References
  • Chapter 18. Acute Lymphoblastic Leukemia
    • Abstract
    • Incidence of ALL
    • Etiology
    • Clinical Features of ALL
    • Prognostic Factors
    • Treatment
    • Infant Leukemia
    • Philadelphia-Positive ALL
    • Down Syndrome and ALL
    • Relapse in Children with ALL
    • Future Drugs in ALL Therapy
    • Further Reading and References
  • Chapter 19. Acute Myeloid Leukemia
    • Abstract
    • Incidence and Epidemiology
    • Etiology and Predisposing Conditions
    • Clinical Features
    • Diagnosis
    • Classification of AML
    • Treatment
    • Novel Therapeutic Approaches
    • Acute Promyelocytic Leukemia
    • AML Special Subgroups
    • Further Reading and References
  • Chapter 20. Histiocytosis Syndromes
    • Abstract
    • Langerhans Cell Histiocytosis
    • Other Histiocytic Disorders
    • Macrophage Mediated Disorders
    • Further Reading and References
  • Chapter 21. Hodgkin Lymphoma
    • Abstract
    • Etiology and Epidemiology
    • Risk Factors
    • Biology
    • Pathology
    • Clinical Presentation
    • Diagnostic Evaluation and Staging
    • Prognostic Factors
    • Treatment
    • Long-Term Complications
    • Follow-Up Evaluations
    • Further Reading and References
  • Chapter 22. Non-Hodgkin Lymphoma
    • Abstract
    • Introduction
    • Incidence and Epidemiology
    • Pathologic Classification
    • Clinical Features
    • Diagnosis
    • Staging
    • Prognosis
    • Management
    • Lymphoblastic Lymphoma
    • B Lineage NHL
    • Further Reading and References
  • Chapter 23. Central Nervous System Malignancies
    • Abstract
    • Epidemiology
    • Pathology
    • Clinical Manifestations
    • Genetic Syndromes Associated with Pediatric Brain Tumors
    • Diagnostic Evaluation
    • Treatment
    • Astrocytomas
    • Medulloblastoma
    • Relapsed Medulloblastoma
    • Brain Stem Tumors
    • Ependymomas
    • Optic Glioma
    • Craniopharyngiomas
    • Intracranial Germ Cell Tumors
    • Malignant Brain Tumors in Infants and Children Less Than 3 Years of Age
    • Further Reading and References
  • Chapter 24. Neuroblastoma
    • Abstract
    • Epidemiology
    • Predisposition
    • Pathology and Biology
    • Clinical Features
    • Diagnosis and Staging
    • Treatment
    • Prognosis, Risk Stratification, and Therapy
    • Post-Therapy Monitoring
    • Special Treatment Considerations
    • Neuroblastoma in the Adolescent and Young Adult
    • Further Reading and References
  • Chapter 25. Renal Tumors
    • Abstract
    • Wilms’ Tumor
    • Nephroblastomatosis
    • Congenital Mesoblastic Nephroma
    • Clear Cell Sarcoma of the Kidney
    • Rhabdoid Tumor of the Kidney
    • Renal Cell Carcinoma
    • Further Reading and References
  • Chapter 26. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas
    • Abstract
    • Incidence and Epidemiology
    • Pathologic and Genetic Classification
    • Clinical Features
    • Diagnostic Evaluation
    • Staging
    • Prognosis
    • Treatment
    • Follow-Up After Completion of Therapy
    • Recurrent Disease
    • Future Perspectives
    • Further Reading and References
  • Chapter 27. Malignant Bone Tumors
    • Abstract
    • Osteosarcoma
    • Ewing Sarcoma Family of Tumors
    • Other Bone Tumors
    • Further Reading and References
  • Chapter 28. Retinoblastoma
    • Abstract
    • Incidence
    • Classification
    • 13q Deletion Syndrome
    • Risk for Second Malignant Neoplasms
    • Pathology
    • Clinical Features
    • Diagnostic Procedures
    • Treatment
    • Posttreatment Management
    • Future Perspectives
    • Further Reading and References
  • Chapter 29. Germ Cell Tumors
    • Abstract
    • Incidence
    • Pathology
    • Clinical Features
    • Diagnostic Evaluation
    • Tumor Markers
    • Staging
    • Treatment
    • Further Reading and References
  • Chapter 30. Hepatic Tumors
    • Abstract
    • Incidence
    • Epidemiology
    • Pathology
    • Clinical Features
    • Diagnostic Evaluation
    • Staging
    • Treatment
    • Follow-up
    • Prognosis
    • Further Reading and References
  • Chapter 31. Hematopoietic Stem Cell Transplantation
    • Abstract
    • Allogeneic Stem Cell Transplantation
    • HSC Sources, Collection, and Manipulation
    • Engraftment
    • Complications of HSCT
    • Late Sequelae of Stem Cell Transplantation
    • Further Reading and References
  • Chapter 32. Management of Oncologic Emergencies
    • Abstract
    • Metabolic Emergencies
    • Cardiothoracic Emergencies
    • Abdominal Emergencies
    • Renal Emergencies
    • Neurologic Emergencies
    • Endocrine Emergencies
    • Treatment-Associated Emergencies
    • Further Reading and References
  • Chapter 33. Supportive Care of Patients with Cancer
    • Abstract
    • Management of Infectious Complications
    • Infection Prophylaxis
    • Recognition and Management of Nausea and Vomiting
    • Mucositis
    • Pain Management
    • Nutritional Status of the Oncology Patient
    • Utilization of Hematopoietic Growth Factors
    • Management of Acute Radiation Side Effects
    • Management of CVCs
    • Posttreatment Immunizations
    • Palliative Care
    • Further Reading and References
  • Chapter 34. Evaluation, Investigations, and Management of Late Effects of Childhood Cancer
    • Abstract
    • Musculoskeletal System
    • Cardiovascular System
    • Respiratory System
    • Central Nervous System
    • Endocrine System
    • Genitourinary System
    • Ocular System
    • Auditory System
    • Gastrointestinal System
    • Immunologic System
    • Obesity
    • Second Malignant Neoplasms
    • Psychosocial Issues
    • Further Reading and References
  • Chapter 35. Psychosocial Aspects of Cancer for Children and Their Families
    • Abstract
    • Time of Diagnosis
    • Treatment Initiation
    • Illness Stabilization
    • During Relapses and Recurrences
    • Treatment Outcomes: The Unsuccessful Course
    • Treatment Outcomes: The Successful Course
    • Conclusion
    • Further Reading and References
  • Chapter 36. Blood Banking Principles and Practices
    • Abstract
    • Introduction
    • Donor Selection and Collection
    • Component Preparation
    • Blood Component Modifications
    • Special Pediatric Population Needs
    • Administration
    • Summary
    • Further Reading and References
  • Appendix 1. Hematological Reference Values
    • Fetal and Cord Blood Hematologic Value
    • Red Cell Values and Related Serum Values
    • White Cell Values
    • Platelet Values
    • Coagulation Values
    • Bone Marrow Cells
  • Appendix 2. Biological Tumor Markers
  • Index

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